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Molecules 2017, 22(3), 424; doi:10.3390/molecules22030424

β-Defensins in the Fight against Helicobacter pylori

1
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II’, 80131 Napoli, Italy
2
CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, Italy
3
Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Seconda Università degli Studi di Napoli, Via G. Vivaldi 42, 81100 Caserta, Italy
4
Dipartimento di Farmacia, Università degli Studi di Napoli ‘Federico II’, Via Montesano 49, 80131 Napoli, Italy
*
Authors to whom correspondence should be addressed.
Academic Editors: Paula Gomes and Stefania Galdiero
Received: 5 January 2017 / Accepted: 4 March 2017 / Published: 7 March 2017
(This article belongs to the Special Issue Peptide-Based Drugs and Drug Delivery Systems)
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Abstract

Antimicrobial peptides (AMPs) play a pivotal role in the innate immune responses to Helicobacter pylori (Hp) in humans. β-Defensins, a class of cationic arginine-rich AMPs, are small peptides secreted by immune cells and epithelial cells that exert antimicrobial activity against a broad spectrum of microorganisms, including Gram-positive and Gram-negative bacteria and fungi. During Hp infections, AMP expression is able to eradicate the bacteria, thereby preventing Hp infections in gastrointestinal tract. It is likely that gastric β-defensins expression is increased during Hp infection. The aim of this review is to focus on increased knowledge of the role of β-defensins in response to Hp infection. We also briefly discuss the potential use of AMPs, either alone or in combination with conventional antibiotics, for the treatment of Hp infection. View Full-Text
Keywords: defensins; Helicobacter pylori; gastric disease; antimicrobial therapy defensins; Helicobacter pylori; gastric disease; antimicrobial therapy
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Pero, R.; Coretti, L.; Nigro, E.; Lembo, F.; Laneri, S.; Lombardo, B.; Daniele, A.; Scudiero, O. β-Defensins in the Fight against Helicobacter pylori. Molecules 2017, 22, 424.

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