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Molecules 2017, 22(3), 365; doi:10.3390/molecules22030365

Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance

1
Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, Delhi 110007, India
2
Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi 110007, India
3
Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy
4
Nucleic Acids Research Lab, Department of Chemistry, University of Delhi (North Campus), Delhi 110007, India
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 27 January 2017 / Revised: 21 February 2017 / Accepted: 23 February 2017 / Published: 27 February 2017
(This article belongs to the Special Issue Chemistry and Pharmacology of Modulators of Oxidative Stress)
View Full-Text   |   Download PDF [550 KB, uploaded 27 February 2017]   |  

Abstract

Epilepsy is a neurological disorder affecting around 1%–2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response. View Full-Text
Keywords: epilepsy; ABC transporters; oxidative stress; antiepileptic drugs; pharmacoresistance epilepsy; ABC transporters; oxidative stress; antiepileptic drugs; pharmacoresistance
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Grewal, G.K.; Kukal, S.; Kanojia, N.; Saso, L.; Kukreti, S.; Kukreti, R. Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance. Molecules 2017, 22, 365.

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