Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance
AbstractEpilepsy is a neurological disorder affecting around 1%–2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response. View Full-Text
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Grewal, G.K.; Kukal, S.; Kanojia, N.; Saso, L.; Kukreti, S.; Kukreti, R. Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance. Molecules 2017, 22, 365.
Grewal GK, Kukal S, Kanojia N, Saso L, Kukreti S, Kukreti R. Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance. Molecules. 2017; 22(3):365.Chicago/Turabian Style
Grewal, Gurpreet K.; Kukal, Samiksha; Kanojia, Neha; Saso, Luciano; Kukreti, Shrikant; Kukreti, Ritushree. 2017. "Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance." Molecules 22, no. 3: 365.
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