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Molecules 2017, 22(3), 357; doi:10.3390/molecules22030357

Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents

1
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
2
Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah 21514, Saudi Arabia
3
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Academic Editor: Philippe Belmont
Received: 9 January 2017 / Revised: 19 February 2017 / Accepted: 24 February 2017 / Published: 26 February 2017
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [554 KB, uploaded 27 February 2017]   |  

Abstract

This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6aj and spirooxindole-spiropiperidinone-pyrrolizines 8aj, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin, sarcosine, and l-proline, through a decarboxylative route with dipolarophile 4aj. All of the newly synthesized compounds were evaluated for their antimicrobial activities and their minimum inhibitory concentration (MIC) against most of the test organisms. The tested compounds displayed excellent activity against all of the tested microorganisms. View Full-Text
Keywords: isatin; sarcosine; l-proline; azomethineylide; 1,3-dipolar cycloaddition; antimicrobial activity isatin; sarcosine; l-proline; azomethineylide; 1,3-dipolar cycloaddition; antimicrobial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hassaneen, H.M.E.; Eid, E.M.; Eid, H.A.; Farghaly, T.A.; Mabkhot, Y.N. Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents. Molecules 2017, 22, 357.

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