A General Asymmetric Synthesis of (R)-Matsutakeol and Flavored Analogs
AbstractAn efficient and practical synthetic route toward chiral matsutakeol and analogs was developed by asymmetric addition of terminal alkyne to aldehydes. (R)-matsutakeol and other flavored substances were feasibly synthesized from various alkylaldehydes in high yield (up to 49.5%, in three steps) and excellent enantiomeric excess (up to >99%). The protocols may serve as an alternative asymmetric synthetic method for active small-molecule library of natural fatty acid metabolites and analogs. These chiral allyl alcohols are prepared for food analysis and screening insect attractants. View Full-Text
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Liu, J.; Li, H.; Zheng, C.; Lu, S.; Guo, X.; Yin, X.; Na, R.; Yu, B.; Wang, M. A General Asymmetric Synthesis of (R)-Matsutakeol and Flavored Analogs. Molecules 2017, 22, 364.
Liu J, Li H, Zheng C, Lu S, Guo X, Yin X, Na R, Yu B, Wang M. A General Asymmetric Synthesis of (R)-Matsutakeol and Flavored Analogs. Molecules. 2017; 22(3):364.Chicago/Turabian Style
Liu, Jia; Li, Honglian; Zheng, Chao; Lu, Shichao; Guo, Xianru; Yin, Xinming; Na, Risong; Yu, Bin; Wang, Min. 2017. "A General Asymmetric Synthesis of (R)-Matsutakeol and Flavored Analogs." Molecules 22, no. 3: 364.
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