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Molecules 2017, 22(3), 359; doi:10.3390/molecules22030359

Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway

College of Pharmacy of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China
Authors to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 5 February 2017 / Revised: 22 February 2017 / Accepted: 23 February 2017 / Published: 27 February 2017
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Paeoniflorin (PF) is an active ingredient of Paeoniae Radix which possesses the neuroprotective effect. However, so far, the neuroprotective mechanism of PF has still not been fully uncovered. The Ca2+/Ca2+/calmodulin-dependent protein kinase II (CaMKII)/cAMP response element-binding (CREB) signaling pathway plays an important role in the intracellular signal transduction pathway involved in cell proliferation, cell survival, inflammation and metabolism. Herein, the neuroprotective roles of PF in the models of middle cerebral artery occlusion (MCAO) followed by reperfusion in rats and N-methyl-d-aspartic acid (NMDA)-induced excitotoxicity in primary hippocampal neurons were investigated. Moreover, we attempted to confirm the hypothesis that its protection effect is via the modulation of the Ca2+/CaMKI)/CREB signaling pathway. In this study, PF not only significantly decreased neurological deficit scores and infarct volume in vivo, but also improved neurons’ cell viability, and inhibited neurons’ apoptosis and intracellular Ca2+ concentration in vitro. Furthermore, PF significantly up-regulated p-CREB and p-CaMKII, and down-regulated calmodulin (CaM) in vivo and in vitro. The results indicate that the protective effect of PF on cerebral ischemia reperfusion injury is possible through regulating the Ca2+/CaMKII/CREB signaling pathway. View Full-Text
Keywords: ischemic stroke; paeoniflorin; middle cerebral artery occlusion; CREB; CaMKII ischemic stroke; paeoniflorin; middle cerebral artery occlusion; CREB; CaMKII

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, Y.; Qiao, L.; Xu, W.; Wang, X.; Li, H.; Xu, W.; Chu, K.; Lin, Y. Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway. Molecules 2017, 22, 359.

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