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Molecules 2017, 22(2), 251; doi:10.3390/molecules22020251

Zunyimycins B and C, New Chloroanthrabenzoxocinones Antibiotics against Methicillin-Resistant Staphylococcus aureus and Enterococci from Streptomyces sp. FJS31-2

1
Guizhou Key Laboratory of Microbial Resources & Drug Development, Zunyi Medical University, Zunyi 563003, Guizhou, China
2
Zunyi Key Laboratory of Genetic Diagnosis & Targeted Drug Therapy, The First People’s Hospital of Zunyi, Zunyi 563003, Guizhou, China
3
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
4
Department of Clinical Laboratory Medicine, Zunyi Medical University, Zunyi 563003, Guizhou, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 9 January 2017 / Revised: 5 February 2017 / Accepted: 5 February 2017 / Published: 8 February 2017
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1404 KB, uploaded 8 February 2017]   |  

Abstract

This study performed an optimization of the fermentation conditions to activate the expression of the zunyimycin family biosynthesis genes of the zunyimycin-producing streptomycetes strain Streptomyces sp. FJS31-2. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of the zunyimycin derivatives, namely, 31-2-7 and 31-2-8, accompanied with three known anthrabenzoxocinones family members of zunyimycin A, BE24566B, and chloroanthrabenzoxocinone. Their structures were elucidated by NMR, HRESIMS, IR, UV, and CD. Results showed that these two compounds were structurally similar to the previously reported compound zunyimycin A but differed in positions and number of chlorine atom substitution. The two novel compounds were called zunyimycins B and C. Antibacterial activity assay indicated that zunyimycin C showed a good inhibitory effect on the methicillin-resistant Staphylococcus aureus and Enterococci. View Full-Text
Keywords: zunyimycins; chloroanthrabenzoxocinones; antibacterial; activity; MRSA; Enterococci; streptomycetes zunyimycins; chloroanthrabenzoxocinones; antibacterial; activity; MRSA; Enterococci; streptomycetes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lü, Y.; Shao, M.; Wang, Y.; Qian, S.; Wang, M.; Wang, Y.; Li, X.; Bao, Y.; Deng, C.; Yue, C.; Liu, D.; Liu, N.; Liu, M.; Huang, Y.; Chen, Z.; Hu, Y. Zunyimycins B and C, New Chloroanthrabenzoxocinones Antibiotics against Methicillin-Resistant Staphylococcus aureus and Enterococci from Streptomyces sp. FJS31-2. Molecules 2017, 22, 251.

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