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Molecules 2017, 22(12), 2072; doi:10.3390/molecules22122072

Coumarin Derivatives Solvent-Free Synthesis under Microwave Irradiation over Heterogeneous Solid Catalysts

1
Skikda Higher School of Technological Education, Azzaba 21300, Algeria
2
Departamento de Química Orgánica, Instituto Universitario de Investigación en Química Fina y Nanoquímica IUIQFN, Facultad de Ciencias, Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie, E-14071 Córdoba, Spain
3
Applied Chemistry Laboratory (ACL), Faculty of Mathematics, Informatics and Materials Sciences, Department of Materials Science, Guelma 24000, Algeria
*
Authors to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 15 November 2017 / Accepted: 23 November 2017 / Published: 28 November 2017
(This article belongs to the Special Issue Meeting of the Spanish Catalysis Society (SECAT’17))
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Abstract

A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materials—Amberlyst-15, zeolite β and sulfonic acid functionalized hybrid silica—in solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail. 7-Hydroxy-4-methylcoumarin and 4-methylcoumarin were obtained in 97% and 43% yields, respectively, over Amberlyst-15. This was the most active catalyst in the Pechmann reaction under studied conditions. View Full-Text
Keywords: phenol; ethyl acetoacetate; solvent-free; microwave irradiation; heterogeneous acid catalysts phenol; ethyl acetoacetate; solvent-free; microwave irradiation; heterogeneous acid catalysts
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bouasla, S.; Amaro-Gahete, J.; Esquivel, D.; López, M.I.; Jiménez-Sanchidrián, C.; Teguiche, M.; Romero-Salguero, F.J. Coumarin Derivatives Solvent-Free Synthesis under Microwave Irradiation over Heterogeneous Solid Catalysts. Molecules 2017, 22, 2072.

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