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Molecules 2017, 22(10), 1743; doi:10.3390/molecules22101743

Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries

1
LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, P-4169-007 Porto, Portugal
2
Ciências Químicas e das Biomoléculas, Escola Superior de Saúde–Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 400, P-4200-072 Porto, Portugal
3
i3S–Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, P-4200-135 Porto, Portugal
*
Authors to whom correspondence should be addressed.
Received: 29 August 2017 / Revised: 6 October 2017 / Accepted: 12 October 2017 / Published: 18 October 2017
(This article belongs to the Special Issue Peptide-Based Drugs and Drug Delivery Systems)
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Abstract

As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections. View Full-Text
Keywords: antimicrobial; chronic infection; diabetes; peptides; ulcers; wound-healing; skin and soft tissue infections (SSTI) antimicrobial; chronic infection; diabetes; peptides; ulcers; wound-healing; skin and soft tissue infections (SSTI)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gomes, A.; Teixeira, C.; Ferraz, R.; Prudêncio, C.; Gomes, P. Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries. Molecules 2017, 22, 1743.

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