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Molecules 2017, 22(10), 1613; doi:10.3390/molecules22101613

Efficacy of Bioactive Cyclic Peptides in Rheumatoid Arthritis: Translation from In Vitro to In Vivo Models

1
Proxima Concepts Limited, c/o London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
2
Adaptimmune Ltd., 60 Jubilee Ave., Milton Park, Abingdon OX14 4RX, UK
3
Cambridge Blue Ventures Ltd., 21 Arlington St, London SW1A 1RN, UK
4
Synovo GmbH, Paul Ehrlich Str. 15, 72076 Tübingen, Germany
*
Author to whom correspondence should be addressed.
Received: 10 August 2017 / Accepted: 15 September 2017 / Published: 25 September 2017
(This article belongs to the Special Issue Peptide-Based Drugs and Drug Delivery Systems)
View Full-Text   |   Download PDF [6912 KB, uploaded 26 September 2017]   |  

Abstract

Using a novel drug discovery technology reported in previous issues of this journal cyclic peptides have been created which are able to down-regulate secretion of inflammatory cytokines, in vitro, by stimulated cells of the macrophage cell line J774. The cytokines in question, TNF-alpha and IL-6, are strongly implicated in etiology of diseases such as rheumatoid arthritis. Studies are reported here using the CAIA animal model for rheumatoid arthritis, which show that the peptides identified are indeed able to impact on inflammation of joints, induced in vivo. The results suggest that these peptides are effective at a dose which could be viable in man, and at which no adverse side effects are evident in the short term. View Full-Text
Keywords: cyclic peptide; TNF; interleukin 6; rheumatoid arthritis; lipoamino acid cyclic peptide; TNF; interleukin 6; rheumatoid arthritis; lipoamino acid
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MDPI and ACS Style

New, R.; Bogus, M.; Bansal, G.S.; Dryjska, M.; Zajkowska, K.; Burnet, M. Efficacy of Bioactive Cyclic Peptides in Rheumatoid Arthritis: Translation from In Vitro to In Vivo Models. Molecules 2017, 22, 1613.

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