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Molecules 2017, 22(10), 1755; doi:10.3390/molecules22101755

Hepatoprotective Effects of Kaempferol-3-O-α-l-Arabinopyranosyl-7-O-α-l-Rhamnopyranoside on d-Galactosamine and Lipopolysaccharide Caused Hepatic Failure in Mice

1
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
2
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China
3
Department of Laboratory Medicine, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 750004, China
*
Author to whom correspondence should be addressed.
Received: 27 September 2017 / Revised: 10 October 2017 / Accepted: 13 October 2017 / Published: 18 October 2017
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Abstract

Fulminant hepatic failure (FHF), associated with high mortality, is characterized by extensive death of hepatocytes and hepatic dysfunction. There is no effective treatment for FHF. Several studies have indicated that flavonoids can protect the liver from different factor-induced injury. Previously, we found that the extracts of Elaeagnus mollis leaves had favorable protective effects on acute liver injury. However, the role and mechanisms behind that was elusive. This study examined the hepatoprotective mechanisms of kaempferol-3-O-α-l-arabinopyranosyl-7-O-α-l-rhamnopyra-noside (KAR), a major flavonol glycoside of E. mollis, against d-galactosamine (GalN) and lipopolysaccharide (LPS)-induced hepatic failure. KAR reduces the mouse mortality, protects the normal liver structure, inhibits the serum aspartate aminotransferase (AST) and alamine aminotransferase (ALT) activity and decreases the production of malondialdehyde (MDA) and reactive oxygen species (ROS) and inflammatory cytokines, TNF-α, IL-6, and IL-1β. Furthermore, KAR inhibits the apoptosis of hepatocytes and reduces the expression of TLR4 and NF-κB signaling pathway-related proteins induced by GalN/LPS treatment. These findings suggest that the anti-oxidative, anti-inflammatory, and anti-apoptotic effects of KAR on GalN/LPS-induced acute liver injury were performed through down-regulating the activity of the TLR4 and NF-κB signaling pathways. View Full-Text
Keywords: Elaeagnus mollis Diels; kaempferol-3-O-α-l-arabinopyranosyl-7-O-α-l-rhamnopyranoside; acute hepatic failure; apoptosis; inflammatory responses Elaeagnus mollis Diels; kaempferol-3-O-α-l-arabinopyranosyl-7-O-α-l-rhamnopyranoside; acute hepatic failure; apoptosis; inflammatory responses
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MDPI and ACS Style

Dong, L.; Yin, L.; Quan, H.; Chu, Y.; Lu, J. Hepatoprotective Effects of Kaempferol-3-O-α-l-Arabinopyranosyl-7-O-α-l-Rhamnopyranoside on d-Galactosamine and Lipopolysaccharide Caused Hepatic Failure in Mice. Molecules 2017, 22, 1755.

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