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Molecules 2017, 22(10), 1680; doi:10.3390/molecules22101680

Natriuretic Peptides: The Case of Prostate Cancer

Dipartimento di Medicina Sperimentale, Università di Perugia, 06123 Perugia, Italy
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Received: 13 September 2017 / Revised: 28 September 2017 / Accepted: 7 October 2017 / Published: 10 October 2017
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Cardiac natriuretic peptides have long been known to act as main players in the homeostatic control of blood pressure, salt and water balance. However, in the last few decades, new properties have been ascribed to these hormones. A systematic review of English articles using MEDLINE Search terms included prostate cancer, inflammation, cardiac hormones, atrial natriuretic peptide, and brain natriuretic peptide. Most recent publications were selected. Natriuretic peptides are strongly connected to the immune system, whose two branches, innate and adaptive, are finely tuned and organized to kill invaders and repair injured tissues. These peptides control the immune response and act as anti-inflammatory and immune-modulatory agents. In addition, in cancers, natriuretic peptides have anti-proliferative effects by molecular mechanisms based on the inhibition/regulation of several pathways promoting cell proliferation and survival. Nowadays, it is accepted that chronic inflammation is a crucial player in prostate cancer development and progression. In this review, we summarize the current knowledge on the link between prostate cancer and inflammation and the potential use of natriuretic peptides as anti-inflammatory and anticancer agents. View Full-Text
Keywords: cardiac hormones; ANP; BNP; inflammation; cancer therapy cardiac hormones; ANP; BNP; inflammation; cancer therapy
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Mezzasoma, L.; Peirce, M.J.; Minelli, A.; Bellezza, I. Natriuretic Peptides: The Case of Prostate Cancer. Molecules 2017, 22, 1680.

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