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Molecules 2017, 22(9), 1495; doi:10.3390/molecules22091495

The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer

1
Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University, Changchun 130000, China
2
Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310000, China
*
Author to whom correspondence should be addressed.
Received: 19 July 2017 / Revised: 4 September 2017 / Accepted: 5 September 2017 / Published: 8 September 2017
(This article belongs to the Special Issue Peptide-Based Drugs and Drug Delivery Systems)
View Full-Text   |   Download PDF [4752 KB, uploaded 8 September 2017]   |  

Abstract

Glutathione peroxidase (GPx) is an antioxidant protein containing selenium. Owing to the limitations of native GPx, considerable efforts have been made to develop GPx mimics. Here, a short 5-mer peptides (5P) was synthesized and characterized using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Enzyme coupled assays were used to evaluate GPx activity. The cell viability and apoptosis of H22 cells were tested, and mice bearing H22 cell-derived tumors were used to determine the effects of 5P on tumor inhibition. In comparison with other enzyme models, 5P provided a suitable substrate with proper catalytic site positions, resulting in enhanced catalytic activity. In our mouse model, 5P showed excellent inhibition of tumor growth and improved immunity. In summary, our findings demonstrated the design and synthesis of the small 5P molecule, which inhibited tumor growth and improved immunity. Notably, 5P could inhibit tumor growth without affecting normal growth. Based on these advantages, the novel mimic may have several clinical applications. View Full-Text
Keywords: glutathione peroxidase mimic; selenium-containing peptide; tumor; liver cancer; immunity glutathione peroxidase mimic; selenium-containing peptide; tumor; liver cancer; immunity
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Yin, J.; Wang, B.; Zhu, X.; Qu, X.; Huang, Y.; Lv, S.; Mu, Y.; Luo, G. The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer. Molecules 2017, 22, 1495.

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