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Molecules 2017, 22(1), 94; doi:10.3390/molecules22010094

Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids

Post Graduation Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970 João Pessoa, PB, Brazil
Post Graduation in Development and Technological Innovation in Medicines, Federal University of Paraiba, 58051-900 João Pessoa, PB, Brazil
Department of Chemistry and Physics, Agrarian Sciences Center, Federal University of Paraíba, 58397-972 Areia, PB, Brazil
Department of Molecular Sciences, Federal Rural University of Pernambuco, Campus Dois Irmãos, 52171-900 Recife, PE, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 12 November 2016 / Revised: 23 December 2016 / Accepted: 26 December 2016 / Published: 6 January 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1038 KB, uploaded 6 January 2017]   |  


The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6′′-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries. View Full-Text
Keywords: Sida rhombifolia; Malvaceae; indoquinoline alkaloids; vasorelaxant activity Sida rhombifolia; Malvaceae; indoquinoline alkaloids; vasorelaxant activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chaves, O.S.; Teles, Y.C.F.; Monteiro, M.M.O.; Mendes Junior, L.G.; Agra, M.F.; Braga, V.A.; Silva, T.M.S.; Souza, M.F.V. Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids. Molecules 2017, 22, 94.

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