Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus
AbstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease involving multiple organs and tissues, which is characterized by the presence of excessive anti-nuclear autoantibodies. The pathogenesis of SLE has been intensively studied but remains far from clear. Increasing evidence has shown that the genetic susceptibilities and environmental factors-induced abnormalities in immune cells, dysregulation of apoptosis, and defects in the clearance of apoptotic materials contribute to the development of SLE. As the main source of auto-antigens, aberrant cell death may play a critical role in the pathogenesis of SLE. In this review, we summarize up-to-date research progress on different levels of cell death—including increasing rate of apoptosis, necrosis, autophagy and defects in clearance of dying cells—and discuss the possible underlying mechanisms, especially epigenetic modifications, which may provide new insight in the potential development of therapeutic strategies for SLE. View Full-Text
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Wu, H.; Fu, S.; Zhao, M.; Lu, L.; Lu, Q. Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus. Molecules 2017, 22, 30.
Wu H, Fu S, Zhao M, Lu L, Lu Q. Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus. Molecules. 2017; 22(1):30.Chicago/Turabian Style
Wu, Haijing; Fu, Siqi; Zhao, Ming; Lu, Liwei; Lu, Qianjin. 2017. "Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus." Molecules 22, no. 1: 30.
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