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Molecules 2016, 21(11), 1565; doi:10.3390/molecules21111565

Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients

1
Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
2
Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Chun Kwok Wong
Received: 25 August 2016 / Revised: 4 November 2016 / Accepted: 14 November 2016 / Published: 18 November 2016
View Full-Text   |   Download PDF [1166 KB, uploaded 18 November 2016]   |  

Abstract

Cytokines are key immunoregulatory molecules that regulate T lymphocyte-mediated immune responses and inflammatory reactions. We determined whether there is aberrant expression of interleukin-27 (IL-27) in rheumatoid arthritis (RA) patients and investigated the clinical significance of these changes. IL-27 is a key cellular factor that regulates the differentiation of CD4+ T cells, which can secrete interleukin-10 (IL-10) and interleukin-17 (IL-17) in vivo. Concentrations of serum IL-27 in 67 RA patients, and 36 sex- and age-matched control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Results showed that concentrations of serum IL-27 in all RA patients were significantly higher than in healthy control subjects, and there was a significant and positive correlation between serum IL-27 levels and disease activity in all RA patients. Levels of serum IL-27 in RA patients were significantly correlated with disease activity score in 28 joints (DAS28). Moreover, immunosuppressive treatment with leflunomide downregulated the levels of IL-27 in active RA patients. Therefore, the elevated production of circulating T cell inflammatory factors contributes to the pathogenesis of RA, and serum IL-27 could potentially serve as a new biomarker of RA disease activity. View Full-Text
Keywords: IL-27; rheumatoid arthritis; inflammation; immune response; disease activity IL-27; rheumatoid arthritis; inflammation; immune response; disease activity
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MDPI and ACS Style

Lai, X.; Wang, H.; Cao, J.; Li, Y.; Dai, Y.; Xiang, Y.; Zhang, L. Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients. Molecules 2016, 21, 1565.

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