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Molecules 2017, 22(1), 159; doi:10.3390/molecules22010159

The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection

Department of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
Academic Editors: Peter Koulen and Thomas J. Schmidt
Received: 29 August 2016 / Revised: 2 January 2017 / Accepted: 11 January 2017 / Published: 19 January 2017
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Abstract

Human neurodegenerative diseases are accompanied by accumulation of heavily oxidized and aggregated proteins. However, the exact molecular reason is not fully elucidated yet. Insufficient cellular protein quality control is thought to play an important role in accumulating covalently oxidized misfolded proteins. Pharmacologically active polyphenols and their derivatives exhibit potential for preventive and therapeutic purposes against protein aggregation during neurodegeneration. Although these compounds act on various biochemical pathways, their role in stabilizing the protein degradation machinery at different stages may be an attractive therapeutical strategy to halt the accumulation of misfolded proteins. This review evaluates and discusses the existing scientific literature on the effect of polyphenols on three major protein degradation pathways: chaperone-mediated autophagy, the proteasome and macroautophagy. The results of these studies demonstrate that phenolic compounds are able to influence the major protein degradation pathways at different levels. View Full-Text
Keywords: protein oxidation; proteostasis; protein degradation; proteasome; macroautophagy; chaperone-mediated autophagy; neuroprotection protein oxidation; proteostasis; protein degradation; proteasome; macroautophagy; chaperone-mediated autophagy; neuroprotection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hajieva, P. The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection. Molecules 2017, 22, 159.

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