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Molecules 2017, 22(1), 163; doi:10.3390/molecules22010163

Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis

State Key Laboratory Cultivation Base for TCM Quality and Efficacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China
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Academic Editor: Derek J. McPhee
Received: 6 December 2016 / Revised: 13 January 2017 / Accepted: 16 January 2017 / Published: 19 January 2017
(This article belongs to the Special Issue Isoprenoid Biosynthesis)
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Abstract

Cornus officinalis and Dioscorea opposita are two traditional Chinese medicines widely used in China for treating diabetes mellitus and its complications, such as diabetic cardiomyopathy. Morroniside (Mor) of Cornus officinalis and diosgenin (Dio) of Dioscorea opposita formed an innovative formula named M + D. The aims of the present study were to investigate myocardial protective effect of M + D on diabetic cardiomyopathy (DCM) through the inhibition of expression levels of caspase-3 protein, and identify the advantage of M + D compared with Mor, Dio, and the positive drug metformin (Met). We detected cell viability, cell apoptosis, intracellular reactive oxygen species (ROS) levels, and the expression levels of Bcl-2, Bax, and caspase-3 protein in rat cardiomyocytes. In result, Mor, Dio, and M + D increased cell viability, inhibited cell apoptosis and decreased ROS levels. Additionally, the expression of Bax and Bcl-2 protein was modulated and the expression levels of caspase-3 protein were markedly decreased. Among the treatment groups, M + D produced the most prominent effects. In conclusion, our data showed for the first time that Mor, Dio, and M + D prevented high glucose (HG)-induced myocardial injury by reducing oxidative stress and apoptosis in rat cardiomyocytes. Among all the groups, M + D produced the strongest effect, while Mor and Dio produced weaker effects. View Full-Text
Keywords: morroniside; diosgenin; cardiomyocytes; diabetic cardiomyopathy; Bcl-2/Bax/caspase-3 signaling pathway morroniside; diosgenin; cardiomyocytes; diabetic cardiomyopathy; Bcl-2/Bax/caspase-3 signaling pathway
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MDPI and ACS Style

Pi, W.-X.; Feng, X.-P.; Ye, L.-H.; Cai, B.-C. Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis. Molecules 2017, 22, 163.

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