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Molecules 2017, 22(1), 106; doi:10.3390/molecules22010106

Phosphorylated Radix Cyathulae officinalis Polysaccharides Act as Adjuvant via Promoting Dendritic Cell Maturation

1
Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, China
2
College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
3
Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610051, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Quan-Bin Han
Received: 16 November 2016 / Revised: 24 December 2016 / Accepted: 4 January 2017 / Published: 10 January 2017
(This article belongs to the Special Issue Natural Polysaccharides)
View Full-Text   |   Download PDF [3001 KB, uploaded 10 January 2017]   |  

Abstract

The aim of this study was to investigate whether phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) used as adjuvant with foot-and-mouth disease vaccine (FMDV) can stimulate specific humoral and cellular immune responses in ICR mice. The results demonstrated that pRCPS significantly up-regulated FMDV-specific IgG, IgG1, IgG2b and IgG2a antibody levels and splenocyte proliferation. pRCPS also promoted the killing activities of cytotoxic T lymphocytes (CTL) and natural killer cells (NK). In addition, pRCPS enhanced the expression levels of IL-2, IL-4, and IFN-γ in CD4+ T cells and the level of IFN-γ in CD8+ T cells. Importantly, pRCPS enhanced the expression of MHCII, CD40+, CD86+, and CD80+ in dendritic cells (DCs). This study indicated that phosphorylation modification could increase immune-enhancing activities of RCPS, and pRCPS could promote humoral and cellular immune responses through facilitating DC maturation. View Full-Text
Keywords: Radix Cyathulae polysaccharide; phosphorylation modification; adjuvant; dendritic cell Radix Cyathulae polysaccharide; phosphorylation modification; adjuvant; dendritic cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Feng, H.; McDonough, S.P.; Fan, J.; Yang, S.; Zhao, X.; Lu, Y.; Gan, Y.; Yi, X.; Chang, Y.-F. Phosphorylated Radix Cyathulae officinalis Polysaccharides Act as Adjuvant via Promoting Dendritic Cell Maturation. Molecules 2017, 22, 106.

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