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Molecules 2017, 22(1), 102; doi:10.3390/molecules22010102

Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides

1
Laboratoire BioPeroxIL, Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique, EA 7270, Unité de Formation et de Recherche des Sciences Vie, Terre et Environnement, 21000 Dijon, France
2
Laboratoire BioPeroxIL, Université Bourgogne-Franche Comté, 6 Bd Gabriel, 21000 Dijon, France
3
Laboratoire de Biochimie et Neurosciences, Faculté des Sciences et Techniques, Université Hassan I, BP 577, 26 000 Settat, Morocco
4
Lipness Team, INSERM, Research Center UMR866 and LabEx LipSTIC, Faculté de Médecine, Université de Bourgogne-Franche Comté, 21079 Dijon CEDEX, France
5
Laboratoire Biologie et Santé, Faculté des Sciences Ben M’sik, Université Hassan II-Casablanca, Avenue Cdt Driss El Harti BP 7955, 20100 Casablanca, Morocco
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 October 2016 / Revised: 28 December 2016 / Accepted: 4 January 2017 / Published: 7 January 2017
(This article belongs to the Special Issue Natural Products and Inflammation)
View Full-Text   |   Download PDF [2087 KB, uploaded 7 January 2017]   |  

Abstract

In this study, we aimed to evaluate the antioxidant and anti-inflammatory properties of Opuntia ficus-indica cactus cladode extracts in microglia BV-2 cells. Inflammation associated with microglia activation in neuronal injury can be achieved by LPS exposure. Using four different structurally and biologically well-characterized LPS serotypes, we revealed a structure-related differential effect of LPS on fatty acid β-oxidation and antioxidant enzymes in peroxisomes: Escherichia coli-LPS decreased ACOX1 activity while Salmonella minnesota-LPS reduced only catalase activity. Different cactus cladode extracts showed an antioxidant effect through microglial catalase activity activation and an anti-inflammatory effect by reducing nitric oxide (NO) LPS-dependent production. These results suggest that cactus extracts may possess a neuroprotective activity through the induction of peroxisomal antioxidant activity and the inhibition of NO production by activated microglial cells. View Full-Text
Keywords: acyl-CoA oxidase 1; catalase; β-oxidation; Escherichia coli; lipopolysaccharides; LPS; nitric oxide; Opuntia; peroxisomes; Salmonella minnesota acyl-CoA oxidase 1; catalase; β-oxidation; Escherichia coli; lipopolysaccharides; LPS; nitric oxide; Opuntia; peroxisomes; Salmonella minnesota
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MDPI and ACS Style

Saih, F.-E.; Andreoletti, P.; Mandard, S.; Latruffe, N.; El Kebbaj, M.S.; Lizard, G.; Nasser, B.; Cherkaoui-Malki, M. Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides. Molecules 2017, 22, 102.

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