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Molecules 2016, 21(9), 1188; doi:10.3390/molecules21091188

Bioprinting and Differentiation of Stem Cells

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
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Academic Editor: Derek J. McPhee
Received: 3 June 2016 / Revised: 26 August 2016 / Accepted: 26 August 2016 / Published: 8 September 2016
(This article belongs to the Special Issue Biomaterials and Bioprinting)
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Abstract

The 3D bioprinting of stem cells directly into scaffolds offers great potential for the development of regenerative therapies; in particular for the fabrication of organ and tissue substitutes. For this to be achieved; the lineage fate of bioprinted stem cell must be controllable. Bioprinting can be neutral; allowing culture conditions to trigger differentiation or alternatively; the technique can be designed to be stimulatory. Such factors as the particular bioprinting technique; bioink polymers; polymer cross-linking mechanism; bioink additives; and mechanical properties are considered. In addition; it is discussed that the stimulation of stem cell differentiation by bioprinting may lead to the remodeling and modification of the scaffold over time matching the concept of 4D bioprinting. The ability to tune bioprinting properties as an approach to fabricate stem cell bearing scaffolds and to also harness the benefits of the cells multipotency is of considerable relevance to the field of biomaterials and bioengineering. View Full-Text
Keywords: 3D bioprinting; stem cells; lineage commitment; differentiation; bioinks 3D bioprinting; stem cells; lineage commitment; differentiation; bioinks
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Irvine, S.A.; Venkatraman, S.S. Bioprinting and Differentiation of Stem Cells. Molecules 2016, 21, 1188.

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