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Molecules 2016, 21(9), 1175; doi:10.3390/molecules21091175

C19-Norditerpenoid Alkaloids from Aconitum szechenyianum and Their Effects on LPS-Activated NO Production

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China
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Academic Editor: Michael Wink
Received: 16 July 2016 / Revised: 30 August 2016 / Accepted: 31 August 2016 / Published: 3 September 2016
(This article belongs to the Special Issue Diversity of Alkaloids)
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Abstract

Three new C19-norditerpenoid alkaloids (13), along with two known C19-norditerpenoid alkaloids (45) have been isolated from Aconitum szechenyianum. Their structures were established by extensive spectroscopic techniques and chemical methods as szechenyianine A (1), szechenyianine B (2), szechenyianine C (3), N-deethyl-3-acetylaconitine (4), and N-deethyldeoxyaconitine (5). Additionally, compounds 15 were tested for the inhibition of NO production on LPS-activated RAW264.7 cells with IC50 values of 36.62 ± 6.86, 3.30 ± 0.11, 7.46 ± 0.89, 8.09 ± 1.31, and 11.73 ± 1.94 μM, respectively, while the positive control drug dexamethasone showed inhibitory activity with IC50 value of 8.32 ± 1.45 μM. The structure-activity relationship of aconitine alkaloids were discussed. View Full-Text
Keywords: Aconitum szechenyianum; C19-norditerpenoid alkaloids; anti-inflammatory activity; NO production; structure-activity relationship Aconitum szechenyianum; C19-norditerpenoid alkaloids; anti-inflammatory activity; NO production; structure-activity relationship
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, F.; Yue, Z.; Xie, P.; Zhang, L.; Li, Z.; Song, B.; Tang, Z.; Song, X. C19-Norditerpenoid Alkaloids from Aconitum szechenyianum and Their Effects on LPS-Activated NO Production. Molecules 2016, 21, 1175.

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