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Molecules 2016, 21(9), 1149; doi:10.3390/molecules21091149

Panax Notoginseng Saponins as a Novel Nature Stabilizer for Poorly Soluble Drug Nanocrystals: A Case Study with Baicalein

1
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2
Department of Pharmaceutics, 94th Hospital of People’s Liberation Army, Nanchang 330000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Received: 29 June 2016 / Revised: 9 August 2016 / Accepted: 25 August 2016 / Published: 30 August 2016
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Abstract

This study is aimed at seeking a nature saponin-based stabilizer for drug nanosuspensions. A poorly soluble drug (baicalein, BCL) was used as a model drug. BCL nanosuspensions with particle size of 156 nm were prepared by means of homogenization and converted into BCL nanocrystals (BCL-NC) stabilized with panax notoginseng saponins (PNS). It was found that PNS was able to prevent the aggregation of BCL-NS during storage and improve the redispersibility of BCL-NC after freeze-drying and spray-drying, compared with polymer stabilizer PVPK30. The freeze-dried and spray-dried BCL-NC with PNS exhibited excellent performance as evidenced by scanning_electron_microscope (SEM) analysis. It was the reason that PNS possessed the interfacial property (41.69 ± 0.32 mN/m) and electrostatic effect (−40.1 ± 1.6 mV), which could easily adsorb onto the surface of hydrophobic BCL nanocrystals and prevent from its aggregation. It is concluded that PNS can be used as an effective nature stabilizer for production of drug nanocrystals. View Full-Text
Keywords: nanocrystals; nanosuspensions; panax notoginseng saponins; redispersibility; freeze-drying; spray-drying nanocrystals; nanosuspensions; panax notoginseng saponins; redispersibility; freeze-drying; spray-drying
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xie, Y.; Ma, Y.; Xu, J.; Liu, Y.; Yue, P.; Zheng, Q.; Hu, P.; Yang, M. Panax Notoginseng Saponins as a Novel Nature Stabilizer for Poorly Soluble Drug Nanocrystals: A Case Study with Baicalein. Molecules 2016, 21, 1149.

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