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Molecules 2016, 21(9), 1146; doi:10.3390/molecules21091146

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 July 2016 / Accepted: 3 August 2016 / Published: 29 August 2016
(This article belongs to the Section Natural Products)
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Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM. View Full-Text
Keywords: Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fan, D.; Zhu, G.-Y.; Li, T.; Jiang, Z.-H.; Bai, L.-P. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Molecules 2016, 21, 1146.

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