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Molecules 2016, 21(9), 1129; doi:10.3390/molecules21091129

Triterpenes for Well-Balanced Scar Formation in Superficial Wounds

Department of Oral and Maxillofacial Surgery/Plastic Surgery, Greifswald University Medicine, Ferdinand-Sauerbruch-Str. DZ 7, Greifswald 17475, Germany
Department of Anesthesiology, Anesthesia, Intensive Care-, Emergency- and Pain Medicine, Greifswald University Medicine, Ferdinand-Sauerbruch-Str., Greifswald 17475, Germany
Department of Surgery, Greifswald University Medicine, Ferdinand-Sauerbruch-Str., Greifswald 17475, Germany
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 29 July 2016 / Revised: 22 August 2016 / Accepted: 24 August 2016 / Published: 27 August 2016
(This article belongs to the Collection Triterpenes and Triterpenoids)
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Triterpenes are demonstrably effective for accelerating re-epithelialisation of wounds and known to improve scar formation for superficial lesions. Among the variety of triterpenes, betuline is of particular medical interest. Topical betuline gel (TBG) received drug approval in 2016 from the European Commission as the first topical therapeutic agent with the proven clinical benefit of accelerating wound healing. Two self-conducted randomized intra-individual comparison clinical studies with a total of 220 patients involved in TBG treatment of skin graft surgical wounds have been screened for data concerning the aesthetic aspect of wound healing. Three months after surgery wound treatment with TBG resulted in about 30% of cases with more discreet scars, and standard of care in about 10%. Patients themselves appreciate the results of TBG after 3 months even more (about 50%) compared to standard of care (about 10%). One year after surgery, the superiority of TBG counts for about 25% in comparison with about 10%, and from the patients’ point of view, for 25% compared to 4% under standard of care. In the majority of wound treatment cases, there is no difference visible between TBG treatment and standard of care after 1 year of scar formation. However, in comparison, TBG still offers a better chance for discreet scars and therefore happens to be superior in good care of wounds. View Full-Text
Keywords: triterpene; topical betuline gel; acceleration of healing; wound care; scar formation; aesthetic benefit triterpene; topical betuline gel; acceleration of healing; wound care; scar formation; aesthetic benefit

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kindler, S.; Schuster, M.; Seebauer, C.; Rutkowski, R.; Hauschild, A.; Podmelle, F.; Metelmann, C.; Metelmann, B.; Müller-Debus, C.; Metelmann, H.-R.; Metelmann, I. Triterpenes for Well-Balanced Scar Formation in Superficial Wounds. Molecules 2016, 21, 1129.

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