Three Novel Triterpenoids from Taraxacum officinale Roots
AbstractThree novel lupane-, bauerane-, and euphane-type triterpenoids (1–3), in addition to seven known triterpenoids (4–10)—18β,19β-epoxy-21β-hydroxylupan-3β-yl acetate (4), 21-oxolup-18-en-3β-yl acetate (5), betulin (6), officinatrione (7), 11α-methoxyolean-12-en-3-one (8), eupha-7,24-dien-3-one (9), and 24-oxoeupha-7,24-dien-3β-yl acetate (10)—were isolated from the roots of Taraxacum officinale. Their structures were elucidated on the basis of spectroscopic analyses using 1D and 2D-NMR spectra and electron ionization mass spectrometry (EIMS). The effects of compounds 1–10 on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages were evaluated. Compounds 4, 6, and 10 exhibited similar NO inhibitory activities to NG-monomethyl-l-arginine acetate (l-NMMA). These compounds did not exhibit cytotoxicity at an effective concentration. The results of present study suggest that compounds 4, 6, and 10 have potential as anti-inflammatory disease agents. View Full-Text
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Kikuchi, T.; Tanaka, A.; Uriuda, M.; Yamada, T.; Tanaka, R. Three Novel Triterpenoids from Taraxacum officinale Roots. Molecules 2016, 21, 1121.
Kikuchi T, Tanaka A, Uriuda M, Yamada T, Tanaka R. Three Novel Triterpenoids from Taraxacum officinale Roots. Molecules. 2016; 21(9):1121.Chicago/Turabian Style
Kikuchi, Takashi; Tanaka, Ayaka; Uriuda, Mayu; Yamada, Takeshi; Tanaka, Reiko. 2016. "Three Novel Triterpenoids from Taraxacum officinale Roots." Molecules 21, no. 9: 1121.
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