Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
AbstractPhytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB). View Full-Text
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Lin, C.-J.; Lo, I.-W.; Lin, Y.-C.; Chen, S.-Y.; Chien, C.-T.; Kuo, Y.-H.; Hwang, T.-L.; Liou, S.-S.; Shen, Y.-C. Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya. Molecules 2016, 21, 1167.
Lin C-J, Lo I-W, Lin Y-C, Chen S-Y, Chien C-T, Kuo Y-H, Hwang T-L, Liou S-S, Shen Y-C. Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya. Molecules. 2016; 21(9):1167.Chicago/Turabian Style
Lin, Ching-Jie; Lo, I-Wen; Lin, Yu-Chi; Chen, Shun-Ying; Chien, Ching-Te; Kuo, Yao-Haur; Hwang, Tsong-Long; Liou, Shorong-Shii; Shen, Ya-Ching. 2016. "Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya." Molecules 21, no. 9: 1167.
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