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Molecules 2016, 21(9), 1167; doi:10.3390/molecules21091167

Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya

School of Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan
Department of Life Sciences, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan
Taiwan Forestry Research Institute, Council of Agriculture, Executive Yuan, No. 53, Nanhai Rd., Zhongzheng Dist., Taipei 10066, Taiwan
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, No. 155-1, Sec. 2, Linong St., Beitou District, Taipei 11221, Taiwan
Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan
Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan
Department of Pharmacy, Tajen University, No. 20, Weixin Rd., Yanpu Township, Pingtung 90741, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Efstathia Ioannou
Received: 22 June 2016 / Revised: 12 August 2016 / Accepted: 26 August 2016 / Published: 2 September 2016
(This article belongs to the Special Issue Triterpenes and Triterpenoids 2016)
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Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (14) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB). View Full-Text
Keywords: Aphanamixis polystachya; apotirucallane-type triterpenoid; limonoid; cytotoxicity; anti-inflammatory activity Aphanamixis polystachya; apotirucallane-type triterpenoid; limonoid; cytotoxicity; anti-inflammatory activity

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Lin, C.-J.; Lo, I.-W.; Lin, Y.-C.; Chen, S.-Y.; Chien, C.-T.; Kuo, Y.-H.; Hwang, T.-L.; Liou, S.-S.; Shen, Y.-C. Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya. Molecules 2016, 21, 1167.

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