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Molecules 2016, 21(9), 1167; doi:10.3390/molecules21091167

Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya

1
School of Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan
2
Department of Life Sciences, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan
3
Taiwan Forestry Research Institute, Council of Agriculture, Executive Yuan, No. 53, Nanhai Rd., Zhongzheng Dist., Taipei 10066, Taiwan
4
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, No. 155-1, Sec. 2, Linong St., Beitou District, Taipei 11221, Taiwan
5
Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan
6
Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan
7
Department of Pharmacy, Tajen University, No. 20, Weixin Rd., Yanpu Township, Pingtung 90741, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Efstathia Ioannou
Received: 22 June 2016 / Revised: 12 August 2016 / Accepted: 26 August 2016 / Published: 2 September 2016
(This article belongs to the Special Issue Triterpenes and Triterpenoids 2016)
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Abstract

Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (14) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB). View Full-Text
Keywords: Aphanamixis polystachya; apotirucallane-type triterpenoid; limonoid; cytotoxicity; anti-inflammatory activity Aphanamixis polystachya; apotirucallane-type triterpenoid; limonoid; cytotoxicity; anti-inflammatory activity
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Lin, C.-J.; Lo, I.-W.; Lin, Y.-C.; Chen, S.-Y.; Chien, C.-T.; Kuo, Y.-H.; Hwang, T.-L.; Liou, S.-S.; Shen, Y.-C. Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya. Molecules 2016, 21, 1167.

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