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Molecules 2016, 21(8), 1086; doi:10.3390/molecules21081086

Porphyromonas gingivalis Lipopolysaccharide Induced Proliferation and Activation of Natural Killer Cells in Vivo

1
Department of Prosthodontics, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
2
Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China
*
Author to whom correspondence should be addressed.
Academic Editor: Norbert Latruffe
Received: 27 May 2016 / Revised: 15 August 2016 / Accepted: 16 August 2016 / Published: 19 August 2016
(This article belongs to the Special Issue Natural Products and Inflammation)
View Full-Text   |   Download PDF [2335 KB, uploaded 19 August 2016]   |  

Abstract

Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) promoted different innate immune activation than that promoted by Escherichia coli (E. coli) LPS. In this study, we examined the effect of P. gingivalis LPS on the proliferation and activation of natural killer (NK) cells in vivo and compared that function with that of E. coli LPS. Administration of P. gingivalis LPS to C57BL/6 mice induced stronger proliferation of NK cells in the spleen and submandibular lymph nodes (sLNs) and increased the number of circulating NK cells in blood compared to those treated with E. coli LPS. However, P. gingivalis LPS did not induce interferon-gamma (IFN-γ) production and CD69 expression in the spleen and sLN NK cells in vivo, and this was attributed to the minimal activation of the spleen and sLN dendritic cells (DCs), including low levels of co-stimulatory molecule expression and pro-inflammatory cytokine production. Furthermore, P. gingivalis LPS-treated NK cells showed less cytotoxic activity against Yac-1 target cells than E. coli LPS-treated NK cells. Hence, these data demonstrated that P. gingivalis LPS promoted limited activation of spleen and sLN NK cells in vivo, and this may play a role in the chronic inflammatory state observed in periodontal disease. View Full-Text
Keywords: P. gingivalis LPS; E. coli LPS; NK cells; dendritic cells P. gingivalis LPS; E. coli LPS; NK cells; dendritic cells
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MDPI and ACS Style

Wang, Y.; Zhang, W.; Xu, L.; Jin, J.-O. Porphyromonas gingivalis Lipopolysaccharide Induced Proliferation and Activation of Natural Killer Cells in Vivo. Molecules 2016, 21, 1086.

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