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Correction published on 17 November 2016, see Molecules 2016, 21(11), 1550.

Open AccessArticle
Molecules 2016, 21(7), 949; doi:10.3390/molecules21070949

Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells

1
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2 D02 YN77, Ireland
2
Shannon ABC, South Campus, IT Tralee, Clash, Tralee, Co., Kerry V92 CX88, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 2 June 2016 / Revised: 14 July 2016 / Accepted: 15 July 2016 / Published: 21 July 2016
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1418 KB, uploaded 17 November 2016]   |  

Abstract

We describe a novel improved approach to the synthesis of the important and well-known heat shock protein 70 inhibitor (HSP70), pifithrin-μ, with corresponding and previously unreported characterisation. The first example of a combination study comprising HSP70 inhibitor pifithrin-μ and cisplatin or oxaliplatin is reported. We have determined, using the Chou-Talalay method, (i) moderate synergistic and synergistic effects in co-treating PC-3 prostate cancer cells with pifithrin-μ and cisplatin and (ii) significant synergistic effects including strong synergism in cotreating HT29 colorectal cancer cells with oxaliplatin and pifithrin-μ. View Full-Text
Keywords: synthesis; pifithrin-μ; heat shock protein 70; cancer; platinum; combination study; Chou-Talalay method synthesis; pifithrin-μ; heat shock protein 70; cancer; platinum; combination study; Chou-Talalay method
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

McKeon, A.M.; Egan, A.; Chandanshive, J.; McMahon, H.; Griffith, D.M. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules 2016, 21, 949.

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