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Molecules 2016, 21(6), 798; doi:10.3390/molecules21060798

The Deformation of Polydimethylsiloxane (PDMS) Microfluidic Channels Filled with Embedded Circular Obstacles under Certain Circumstances

Biotechnology Research Division, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 29 Guemgu-gil, Jeongeup, Jeonbuk 56212, South Korea
Department of Textile Engineering & Technology, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, South Korea
Ministry of Employment and Labor, Center for Major Industrial Accident Prevention, 34 Yeosusandan-ro, Yeosu-si, Jeollanam-do 59361, South Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Fan-Gang Tseng and Tuhin Subhra Santra
Received: 20 May 2016 / Revised: 9 June 2016 / Accepted: 16 June 2016 / Published: 18 June 2016
(This article belongs to the Special Issue Micro/Nano Fluidics and Bio-MEMS)
View Full-Text   |   Download PDF [2959 KB, uploaded 18 June 2016]   |  


Experimental investigations were conducted to determine the influence of polydimethylsiloxane (PDMS) microfluidic channels containing aligned circular obstacles (with diameters of 172 µm and 132 µm) on the flow velocity and pressure drop under steady-state flow conditions. A significant PDMS bulging was observed when the fluid flow initially contacted the obstacles, but this phenomenon decreased in the 1 mm length of the microfluidic channels when the flow reached a steady-state. This implies that a microfluidic device operating with steady-state flows does not provide fully reliable information, even though less PDMS bulging is observed compared to quasi steady-state flow. Numerical analysis of PDMS bulging using ANSYS Workbench showed a relatively good agreement with the measured data. To verify the influence of PDMS bulging on the pressure drop and flow velocity, theoretical analyses were performed and the results were compared with the experimental results. The measured flow velocity and pressure drop data relatively matched well with the classical prediction under certain circumstances. However, discrepancies were generated and became worse as the microfluidic devices were operated under the following conditions: (1) restricted geometry of the microfluidic channels (i.e., shallow channel height, large diameter of obstacles and a short microchannel length); (2) operation in quasi-steady state flow; (3) increasing flow rates; and (4) decreasing amount of curing agent in the PDMS mixture. Therefore, in order to obtain reliable data a microfluidic device must be operated under appropriate conditions. View Full-Text
Keywords: PDMS bulging; ANSYS Workbench; embedded obstacles; steady-state flow; pressure drop; flow velocity PDMS bulging; ANSYS Workbench; embedded obstacles; steady-state flow; pressure drop; flow velocity

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Roh, C.; Lee, J.; Kang, C. The Deformation of Polydimethylsiloxane (PDMS) Microfluidic Channels Filled with Embedded Circular Obstacles under Certain Circumstances. Molecules 2016, 21, 798.

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