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Molecules 2016, 21(5), 566; doi:10.3390/molecules21050566

Antimicrobial Activity and Chromatographic Analysis of Extracts from Tropaeolum pentaphyllum Lam. Tubers

1
Departamento de Farmácia Industrial, Universidade Federal de Santa Maria (UFSM), Avenida Roraima 1000, Block 26, Santa Maria 97105-900, Rio Grande do Sul, Brazil
2
Departamento de Parasitologia, Microbiologia e Imunologia, Universidade Federal de Santa Maria (UFSM), Avenida Roraima 1000, Block 20, Santa Maria 97105-900, Rio Grande do Sul, Brazil
3
Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Santa Maria (UFSM), Avenida Roraima 1000, Block 26, Santa Maria 97105-900, Rio Grande do Sul, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 7 March 2016 / Revised: 4 April 2016 / Accepted: 25 April 2016 / Published: 28 April 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [234 KB, uploaded 28 April 2016]   |  

Abstract

Background: Tropaeolum pentaphyllum Lam. tubers (Tropaeolaceae) are known and used as a condiment and for the treatment of skin infections in Southern Brazil. However, its activity and composition has not yet been investigated. Thus, different extracts and the essential oil from the tubers were tested against a range of microorganisms. The most active extracts were submitted to chromatographic analysis. Methods: Hydroalcoholic extract (70%), fractions of it, and the essential oil from the tubers were tested against several bacteria, yeasts and molds, furnishing the corresponding inhibitory, bactericidal and fungicidal minimal concentration values. The most active extracts were submitted to GC-MS investigation. Results: The strongest effects against different strains of microorganisms, such as Gram-positive and negative bacteria, Candida spp. and dermatophytes were observed for the essential oil and the chloroform fraction, with minimal inhibitory concentrations (MICs) well below 200 µg/mL. GC-MS analysis revealed that the major essential oil constituent is benzyl isothiocyanate (BITC), while the chloroform fraction is constituted of BITC, amides, sulfur, fatty acids and its esters, all compounds that may be related to the demonstrated activity. Conclusions: Overall, the results support the popular use of the plant for the treatment of skin infections, and revealed the main active compounds. View Full-Text
Keywords: Tropaeolum pentaphyllum; essential oil; benzyl isothiocyanate; antifungal; antibacterial Tropaeolum pentaphyllum; essential oil; benzyl isothiocyanate; antifungal; antibacterial
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MDPI and ACS Style

da Cruz, R.C.; Denardi, L.B.; Mossmann, N.J.; Piana, M.; Alves, S.H.; de Campos, M.M.A. Antimicrobial Activity and Chromatographic Analysis of Extracts from Tropaeolum pentaphyllum Lam. Tubers. Molecules 2016, 21, 566.

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