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Molecules 2016, 21(5), 564; doi:10.3390/molecules21050564

Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities

1
Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia
2
Department of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, Bratislava 83232, Slovakia
3
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, Slovakia
4
Department of Medical Informatics, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, Košice 04011, Slovakia
5
Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, Košice 04011, Slovakia
6
Department for Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., Ondavská 8, Košice 04011, Slovakia
*
Authors to whom correspondence should be addressed.
Academic Editors: Atanas G. Atanasov, Karel Šmejkal and Elke Heiss
Received: 23 March 2016 / Revised: 21 April 2016 / Accepted: 25 April 2016 / Published: 28 April 2016
(This article belongs to the Special Issue Effects of Natural Products in the Context of Cardiometabolic Disease)
View Full-Text   |   Download PDF [2464 KB, uploaded 28 April 2016]   |  

Abstract

Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week period, changes in blood glucose and body weight were monitored. Then, rats were sacrificed and subjected to the assessment of changes in the reactivity of aortas and measurement of butyrylcholinesterase activity. To complete the panel of experiments, α-glucosidase activity was assessed in vitro. Our results demonstrate that both tested extracts exert similar anti-diabetic activities. However, better anti-oxidant activity of the A. eupatoria extract indicates its higher clinical potential in the prevention and/or adjuvant therapy of developing cardiovascular complications related to DM and diseases associated with oxidative stress. View Full-Text
Keywords: diabetes mellitus; phytotherapy; agrimony; artichoke; streptozotocin diabetes mellitus; phytotherapy; agrimony; artichoke; streptozotocin
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Kuczmannová, A.; Balažová, A.; Račanská, E.; Kameníková, M.; Fialová, S.; Majerník, J.; Nagy, M.; Gál, P.; Mučaji, P. Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities. Molecules 2016, 21, 564.

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