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Molecules 2016, 21(5), 565; doi:10.3390/molecules21050565

Ultrasound-Assisted Enantioselective Esterification of Ibuprofen Catalyzed by a Flower-Like Nanobioreactor

1
College of Horticulture, Jilin Agricultural University, Changchun 130118, China
2
College of Resources and Environment, Jilin Agricultural University, Changchun 130118, China
3
College of Life Science, Jilin Agricultural University, Changchun 130118, China
4
Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 March 2016 / Revised: 22 April 2016 / Accepted: 25 April 2016 / Published: 28 April 2016
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1772 KB, uploaded 28 April 2016]   |  

Abstract

A flower-like nanobioreactor was prepared for resolution of ibuprofen in organic solvents. Ultrasound irradiation has been used to improve the enzyme performance of APE1547 (a thermophilic esterase from the archaeon Aeropyrum pernix K1) in the enantioselective esterification. Under optimum reaction conditions (ultrasound power, 225 W; temperature, 45 °C; water activity, 0.21), the immobilized APE1547 showed an excellent catalytic performance (enzyme activity, 13.26 μmol/h/mg; E value, 147.1). After ten repeated reaction batches, the nanobioreactor retained almost 100% of its initial enzyme activity and enantioselectivity. These results indicated that the combination of the immobilization method and ultrasound irradiation can enhance the enzyme performance dramatically. View Full-Text
Keywords: ibuprofen; APE1547; resolution; ultrasound; nanobioreactor ibuprofen; APE1547; resolution; ultrasound; nanobioreactor
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An, B.; Fan, H.; Wu, Z.; Zheng, L.; Wang, L.; Wang, Z.; Chen, G. Ultrasound-Assisted Enantioselective Esterification of Ibuprofen Catalyzed by a Flower-Like Nanobioreactor. Molecules 2016, 21, 565.

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