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Molecules 2016, 21(4), 477; doi:10.3390/molecules21040477

Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides

1
Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia
2
Department of Microbiology, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia
3
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editors: Joaquín García Álvarez and Jonathan Sperry
Received: 28 February 2016 / Revised: 30 March 2016 / Accepted: 1 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Organic Reaction in Green Solvents)
View Full-Text   |   Download PDF [986 KB, uploaded 19 April 2016]   |  

Abstract

A green protocol has been applied to synthesize a novel series of 3-cyano-2-(tri-O-acetyl-β-d-arabinopyranosylthio)pyridines in a short reaction time, in higher yields and with simpler operations, when compared with the conventional heating method. Deacetylation of the obtained acetylated arabinosides produced 2-(β-d-arabinopyranosylthio)-3-cyanopyridines. The structures of the obtained products were confirmed on the basis of spectroscopic data (FT-IR, 1D, 2D-NMR). The synthesized compounds were screened for the antimicrobial activity against a selection of Gram positive and Gram negative bacteria. View Full-Text
Keywords: 2(1H)-pyridinethione; nucleosides; green synthesis; microwave; solvent-free conditions; antimicrobial 2(1H)-pyridinethione; nucleosides; green synthesis; microwave; solvent-free conditions; antimicrobial
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Maghrabi, I.A.; Alghamdi, S.; Alrobaian, M.; Eldeab, H.A. Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides. Molecules 2016, 21, 477.

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