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Molecules 2016, 21(4), 462; doi:10.3390/molecules21040462

New Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Benzotriazolium-Based Ionic Liquids under Solvent-Free Conditions

1,†
,
1,†
,
1
and
1,2,*
1
Key Laboratory of Oil and Gas Fine Chemicals of Ministry of Education, School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China
2
Physics and Chemistry Detecting Center, Xinjiang University, Urumqi 830046, China
The two authors contributed equally to this paper.
*
Author to whom correspondence should be addressed.
Academic Editors: Joaquín García Álvarez and Jonathan Sperry
Received: 13 March 2016 / Revised: 30 March 2016 / Accepted: 5 April 2016 / Published: 7 April 2016
(This article belongs to the Special Issue Organic Reaction in Green Solvents)
View Full-Text   |   Download PDF [495 KB, uploaded 7 April 2016]   |  

Abstract

An efficient synthesis of novel 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) and their derivatives, using Brønsted acidic ionic liquid [C2O2BBTA][TFA] as a catalyst, from the condensation of aryl aldehyde, β-ketoester and urea was described. Reactions proceeded smoothly for 40 min under solvent-free conditions and gave the desirable products with good to excellent yields (up to 99%). The catalyst could be easily recycled and reused with similar efficacies for at least six cycles. View Full-Text
Keywords: Benzotriazolium-based ionic liquids; Biginelli reaction; synthesis; catalysis Benzotriazolium-based ionic liquids; Biginelli reaction; synthesis; catalysis
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Liu, Z.; Ma, R.; Cao, D.; Liu, C. New Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Benzotriazolium-Based Ionic Liquids under Solvent-Free Conditions. Molecules 2016, 21, 462.

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