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Molecules 2016, 21(4), 450; doi:10.3390/molecules21040450

Anti‐Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic‐Polycytidylic Acid

Department of Pathology, College of Korean Medicine, Gachon University, Seong‐nam 13120, Korea
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Received: 3 February 2016 / Revised: 22 March 2016 / Accepted: 29 March 2016 / Published: 4 April 2016
(This article belongs to the Special Issue Natural Products and Inflammation)
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Abstract

Quercetin (3,3′,4′,5,6‐pentahydroxyflavone) is a well‐known antioxidant and a flavonol found in many fruits, leaves, and vegetables. Quercetin also has known anti‐inflammatory effects on lipopolysaccharide‐induced macrophages. However, the effects of quercetin on virus‐induced macrophages have not been fully reported. In this study, the anti‐inflammatory effect of quercetin on double‐stranded RNA (dsRNA)‐induced macrophages was examined. Quercetin at concentrations up to 50 μM significantly inhibited the production of NO, IL‐6, MCP‐1, IP‐10, RANTES, GM‐CSF, G‐CSF, TNF‐α, LIF, LIX, and VEGF as well as calcium release in dsRNA (50 μg/mL of polyinosinic‐polycytidylic acid)‐induced RAW 264.7 mouse macrophages (p < 0.05). Quercetin at concentrations up to 50 μM also significantly inhibited mRNA expression of signal transducer and activated transcription 1 (STAT1) and STAT3 in dsRNA‐induced RAW 264.7 cells (p < 0.05). In conclusion, quercetin had alleviating effects on viral inflammation based on inhibition of NO, cytokines, chemokines, and growth factors in dsRNA‐induced macrophages via the calcium‐STAT pathway. View Full-Text
Keywords: quercetin; dsRNA; inflammation; macrophages; nitric oxide; cytokine; calcium; STAT quercetin; dsRNA; inflammation; macrophages; nitric oxide; cytokine; calcium; STAT
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, Y.; Park, W. Anti‐Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic‐Polycytidylic Acid. Molecules 2016, 21, 450.

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