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Molecules 2016, 21(3), 312; doi:10.3390/molecules21030312

Synthesis, Characterization and in Vitro Evaluation of Manganese Ferrite (MnFe2O4) Nanoparticles for Their Biocompatibility with Murine Breast Cancer Cells (4T1)

1
Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
2
Department of Physics, Faculty of Science, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
3
Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
4
Department of Crop Science, Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia
5
Department of Applied Science and Humanities, Sasi Intitute of Technology and Engineering, Tadepalligudem, West Godavari District 534101, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Received: 24 December 2015 / Revised: 23 February 2016 / Accepted: 24 February 2016 / Published: 11 March 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
View Full-Text   |   Download PDF [1897 KB, uploaded 11 March 2016]   |  

Abstract

Manganese ferrite (MnFe2O4) magnetic nanoparticles were successfully prepared by a sol-gel self-combustion technique using iron nitrate and manganese nitrate, followed by calcination at 150 °C for 24 h. Calcined sample was systematically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrational sample magnetometry (VSM) in order to identify the crystalline phase, functional group, morphology, particle size, shape and magnetic behavior. It was observed that the resultant spinal ferrites obtained at low temperature exhibit single phase, nanoparticle size and good magnetic behavior. The study results have revealed the existence of a potent dose dependent cytotoxic effect of MnFe2O4 nanoparticles against 4T1 cell lines at varying concentrations with IC50 values of 210, 198 and 171 μg/mL after 24 h, 48 h and 72 h of incubation, respectively. Cells exposed to higher concentrations of nanoparticles showed a progressive increase of apoptotic and necrotic activity. Below 125 μg/mL concentration the nanoparticles were biocompatible with 4T1 cells. View Full-Text
Keywords: manganese ferrite; nanoparticles; magnetization; breast cancer; cytotoxicity manganese ferrite; nanoparticles; magnetization; breast cancer; cytotoxicity
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kanagesan, S.; Aziz, S.B.A.; Hashim, M.; Ismail, I.; Tamilselvan, S.; Alitheen, N.B.B.M.; Swamy, M.K.; Purna Chandra Rao, B. Synthesis, Characterization and in Vitro Evaluation of Manganese Ferrite (MnFe2O4) Nanoparticles for Their Biocompatibility with Murine Breast Cancer Cells (4T1). Molecules 2016, 21, 312.

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