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Molecules 2016, 21(3), 342; doi:10.3390/molecules21030342

Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review

1
Faculdade de Ciências Farmacêuticas, UNESP—Univ. Estadual Paulista, Campus Araraquara, Departamento de Fármacos e Medicamentos, Araraquara 14800-903 SP, Brazil
2
Faculdade de Ciências Farmacêuticas, UNESP—Univ. Estadual Paulista, Campus Araraquara, Departamento de Análises Clínicas, Araraquara 14800-903 SP, Brazil
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Received: 23 December 2015 / Revised: 4 March 2016 / Accepted: 7 March 2016 / Published: 11 March 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
View Full-Text   |   Download PDF [877 KB, uploaded 11 March 2016]   |  

Abstract

Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer. View Full-Text
Keywords: photodynamic therapy; cancer; nanotechnology; drug delivery systems photodynamic therapy; cancer; nanotechnology; drug delivery systems
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Calixto, G.M.F.; Bernegossi, J.; de Freitas, L.M.; Fontana, C.R.; Chorilli, M. Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review. Molecules 2016, 21, 342.

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