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Molecules 2016, 21(3), 304; doi:10.3390/molecules21030304

Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases

1
Laboratory BioperoxIL, Faculty of Sciences SVTE, University of Bourgogne, 6 Bd Gabriel, F-21000 Dijon, France
2
Laboratory of Translational Research, Arcispedale S. Maria Nuova IRCCS, Reggio Emilia 42123, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 2 February 2016 / Revised: 16 February 2016 / Accepted: 23 February 2016 / Published: 2 March 2016
(This article belongs to the Special Issue Natural Products and Inflammation)
View Full-Text   |   Download PDF [592 KB, uploaded 2 March 2016]   |  

Abstract

Resveratrol (3,4′,5 trihydroxy-trans-stilbene) is one of the best known phytophenols with pleiotropic properties. It is a phytoalexin produced by vine and it leads to the stimulation of natural plant defenses but also exhibits many beneficial effects in animals and humans by acting on a wide range of organs and tissues. These include the prevention of cardiovascular diseases, anti-cancer potential, neuroprotective effects, homeostasia maintenance, aging delay and a decrease in inflammation. Age-related macular degeneration (AMD) is one of the main causes of deterioration of vision in adults in developed countries This review deals with resveratrol and ophthalmology by focusing on the antioxidant, anti-inflammatory, and anti-angiogenic effects of this molecule. The literature reports that resveratrol is able to act on various cell types of the eye by increasing the level of natural antioxidant enzymatic and molecular defenses. Resveratrol anti-inflammatory effects are due to its capacity to limit the expression of pro-inflammatory factors, such as interleukins and prostaglandins, and also to decrease the chemo-attraction and recruitment of immune cells to the inflammatory site. In addition to this, resveratrol was shown to possess anti-VEGF effects and to inhibit the proliferation and migration of vascular endothelial cells. Resveratrol has the potential to be used in a range of human ocular diseases and conditions, based on animal models and in vitro experiments. View Full-Text
Keywords: resveratrol; eyes; inflammation resveratrol; eyes; inflammation
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Lançon, A.; Frazzi, R.; Latruffe, N. Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases. Molecules 2016, 21, 304.

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