Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting
Abstract
:1. Introduction
2. Results and Discussion
2.1. Preparation and Characterization of Silymarin-Loaded Nanoparticles
2.2. In Vitro Release Study
2.3. Cytotoxicity Test
2.4. Cell Uptake and Flow Cytometry Study
2.5. Tissue Distribution Study
3. Experimental Section
3.1. Materials
3.2. Synthesis of hm-BSP
3.3. Preparation of Silymarin-Loaded Nanoparticles
3.4. Characterization of Silymarin-Loaded Nanoparticles
3.5. In Vitro Dissolution Study
3.6. Cytotoxicity Test
3.7. Cell Uptake and Flow Cytometry Study
3.8. Tissue Distribution Study
3.9. Data Statistics
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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- Sample Availability: Samples of the nanoparticles are available from the authors.
Sample | Diameter (nm) | PDI | Zeta (mV) a | EE (%) | DL (%) |
---|---|---|---|---|---|
SM-hm-BSP | 200.83 ± 8.10 | 0.25 ± 0.04 | −0.36 ± 0.93 | 78.86 ± 0.66 | 7.31 ± 0.05 |
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Ma, Y.; He, S.; Ma, X.; Hong, T.; Li, Z.; Park, K.; Wang, W. Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting. Molecules 2016, 21, 265. https://doi.org/10.3390/molecules21030265
Ma Y, He S, Ma X, Hong T, Li Z, Park K, Wang W. Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting. Molecules. 2016; 21(3):265. https://doi.org/10.3390/molecules21030265
Chicago/Turabian StyleMa, Yanni, Shaolong He, Xueqin Ma, Tongtong Hong, Zhifang Li, Kinam Park, and Wenping Wang. 2016. "Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting" Molecules 21, no. 3: 265. https://doi.org/10.3390/molecules21030265