Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation
AbstractOil-in-water nanoemulsions are stable systems with droplet sizes in the 20–200 nm range. The physicochemical properties of these systems may be influenced by the addition of additives. Thus, the influence of ethoxylated (EL) and acetylated lanolin (AL) addition on the droplet size, pH values, electrical conductivity and stability of nanoemulsions was investigated. Then, effect of nano-emulsions additives with EL (NE-EL) or AL (NE-AL) in hydration, oiliness and pH of the skin were evaluated. Nanoemulsion safety was evaluated through the observation of no undesirable effects after skin formulation application. Both additives caused changes in droplet size and electrical conductivity, but not in pH values. Nanoemulsions containing up to 6.0% ethoxylated lanolin and 2.0% acetylated lanolin remained stable after centrifugation tests. Higher concentrations of the additives made the nanoemulsions unstable. Stability tests showed that ethoxylated lanolin produced more stable nanoemulsions then acetylated lanolin and that the major instability phenomenon occurring in these systems is coalescence at elevated temperatures. Nanoemulsion-based lanolin derivatives increased skin hydration and oiliness and did not change cutaneous pH values. These formulations are non-toxic since they did not cause any irritation on the skin surface after nanoemulsion application, showing potential as carriers for pharmaceuticals and cosmetic applications. View Full-Text
Share & Cite This Article
Pereira, T.A.; Guerreiro, C.M.; Maruno, M.; Ferrari, M.; Rocha-Filho, P.A. Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation. Molecules 2016, 21, 248.
Pereira TA, Guerreiro CM, Maruno M, Ferrari M, Rocha-Filho PA. Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation. Molecules. 2016; 21(3):248.Chicago/Turabian Style
Pereira, Tatiana A.; Guerreiro, Carolina M.; Maruno, Monica; Ferrari, Marcio; Rocha-Filho, Pedro A. 2016. "Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation." Molecules 21, no. 3: 248.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.