Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces
AbstractDeposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections. View Full-Text
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Oprea, A.E.; Pandel, L.M.; Dumitrescu, A.M.; Andronescu, E.; Grumezescu, V.; Chifiriuc, M.C.; Mogoantă, L.; Bălşeanu, T.-A.; Mogoşanu, G.D.; Socol, G.; Grumezescu, A.M.; Iordache, F.; Maniu, H.; Chirea, M.; Holban, A.M. Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces. Molecules 2016, 21, 220.
Oprea AE, Pandel LM, Dumitrescu AM, Andronescu E, Grumezescu V, Chifiriuc MC, Mogoantă L, Bălşeanu T-A, Mogoşanu GD, Socol G, Grumezescu AM, Iordache F, Maniu H, Chirea M, Holban AM. Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces. Molecules. 2016; 21(2):220.Chicago/Turabian Style
Oprea, Alexandra E.; Pandel, Loredana M.; Dumitrescu, Ana M.; Andronescu, Ecaterina; Grumezescu, Valentina; Chifiriuc, Mariana C.; Mogoantă, Laurenţiu; Bălşeanu, Tudor-Adrian; Mogoşanu, George D.; Socol, Gabriel; Grumezescu, Alexandru M.; Iordache, Florin; Maniu, Horia; Chirea, Mariana; Holban, Alina M. 2016. "Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces." Molecules 21, no. 2: 220.
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