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Molecules 2016, 21(2), 197; doi:10.3390/molecules21020197

New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate

1
Department of Applied Pharmacy, Medical University of Lodz, ul. Muszyńskiego 1, Lodz 90-151, Poland
2
Surface-Active Agent Plant “ICSO Blachownia”, ul. Energetyków 9, Kędzierzyn-Koźle 47-225, Poland
3
Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszyńskiego 1, Lodz 90-151, Poland
4
Laboratory of Radiopharmacy, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszyńskiego 1, Lodz 90-151, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Received: 22 December 2015 / Accepted: 2 February 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
View Full-Text   |   Download PDF [870 KB, uploaded 6 February 2016]   |  

Abstract

As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge. The objective of this study was to determine whether the solubility of megestrol acetate, a Biopharmaceutical Classification System (BCS) class II drug, can be improved by using a newly-synthesized surfactant (Rofam 70: a rapeseed methyl ester ethoxylate) and compare it with two references surfactants (Tween 80, Pluronic F68) at three different pH values. Spectrophotometry was used to compare the solubility profiles in the presence of three tested surfactants at pH 5.0, 7.4 and 9.0. Rapeseed methyl ester ethoxylate was found to improve the solubility of the BCS Class II drug and increase its bioavailability; It increased drug solubility more effectively than Pluronic F68. Its cytotoxicity results indicate its possible value as a surfactant in Medicine and Pharmacy. View Full-Text
Keywords: solubilization; surfactant; nanoparticles; megestrol acetate; Tween 80 solubilization; surfactant; nanoparticles; megestrol acetate; Tween 80
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Lachowicz, M.; Kołodziejczyk, M.; Lukosek, M.; Kosno, J.; Olszewska, P.; Szymański, P. New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate. Molecules 2016, 21, 197.

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