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Molecules 2016, 21(2), 215; doi:10.3390/molecules21020215

Molecular Mechanisms of Inhibition of Streptococcus Species by Phytochemicals

Faculty of Agriculture, Dalhousie University, Truro, NS PO Box 550, Canada
Faculty of Dentistry, Dalhousie University, Halifax, NS PO Box 15000, Canada
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Battino, Etsuo Niki and José L. Quiles
Received: 7 January 2016 / Revised: 4 February 2016 / Accepted: 6 February 2016 / Published: 17 February 2016
(This article belongs to the Special Issue 20th Anniversary of Molecules—Recent Advances in Natural Products)
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This review paper summarizes the antibacterial effects of phytochemicals of various medicinal plants against pathogenic and cariogenic streptococcal species. The information suggests that these phytochemicals have potential as alternatives to the classical antibiotics currently used for the treatment of streptococcal infections. The phytochemicals demonstrate direct bactericidal or bacteriostatic effects, such as: (i) prevention of bacterial adherence to mucosal surfaces of the pharynx, skin, and teeth surface; (ii) inhibition of glycolytic enzymes and pH drop; (iii) reduction of biofilm and plaque formation; and (iv) cell surface hydrophobicity. Collectively, findings from numerous studies suggest that phytochemicals could be used as drugs for elimination of infections with minimal side effects. View Full-Text
Keywords: streptococci; biofilm; adherence; phytochemical; quorum sensing; S. mutans; S. pyogenes; S. agalactiae; S. pneumoniae streptococci; biofilm; adherence; phytochemical; quorum sensing; S. mutans; S. pyogenes; S. agalactiae; S. pneumoniae

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abachi, S.; Lee, S.; Rupasinghe, H.P.V. Molecular Mechanisms of Inhibition of Streptococcus Species by Phytochemicals. Molecules 2016, 21, 215.

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