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Molecules 2016, 21(2), 158; doi:10.3390/molecules21020158

Design and Characterization of a Novel p1025 Peptide-Loaded Liquid Crystalline System for the Treatment of Dental Caries

1
Faculdade de Ciências Farmacêuticas, UNESP—Universidade Estadual Paulista, Campus Araraquara, Araraquara, SP 14800-850, Brazil
2
Instituto de Química, UNESP—Universidade Estadual Paulista, Campus Araraquara, Araraquara, SP 14800-900, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Received: 18 November 2015 / Revised: 19 January 2016 / Accepted: 25 January 2016 / Published: 28 January 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
View Full-Text   |   Download PDF [1191 KB, uploaded 28 January 2016]   |  

Abstract

Dental caries, mainly caused by the adhesion of Streptococcus mutans to pellicle-coated tooth surfaces, is an important public health problem worldwide. A synthetic peptide (p1025) corresponding to residues 1025–1044 of the adhesin can inhibit this binding. Peptides are particularly susceptible to the biological environment; therefore, a p1025 peptide-loaded liquid crystalline system (LCS) consisting of tea tree oil as the oil phase, polyoxypropylene-(5)-polyoxyethylene-(20)-cetyl alcohol as the surfactant, and water or 0.5% polycarbophil polymer dispersions as the aqueous phase was employed as a drug delivery platform. This system exhibited anticaries and bioadhesive properties and provided a protective environment to p1025 at the site of action, thereby modulating its action, prolonging its contact with the teeth, and decreasing the frequency of administration. LCSs were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), and rheological, texture, and bioadhesive tests. PLM and SAXS revealed the presence of hexagonal liquid crystalline phases and microemulsions. Rheological analyses demonstrated that the addition of polymer dispersions favored characteristics such as shear thinning and thixotropy, hence improving buccal application. Bioadhesion tests showed that polymer dispersions contributed to the adhesion onto the teeth. Taken together, LCS could provide a novel pharmaceutical nanotechnology platform for dental caries treatment. View Full-Text
Keywords: nanostructured drug delivery systems; liquid crystalline system; bioadhesive polymers; tea tree oil; dental caries nanostructured drug delivery systems; liquid crystalline system; bioadhesive polymers; tea tree oil; dental caries
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Calixto, G.M.F.; Garcia, M.H.; Cilli, E.M.; Chiavacci, L.A.; Chorilli, M. Design and Characterization of a Novel p1025 Peptide-Loaded Liquid Crystalline System for the Treatment of Dental Caries. Molecules 2016, 21, 158.

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