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Molecules 2016, 21(2), 188; doi:10.3390/molecules21020188

Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China
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Academic Editors: Vassilios Roussis and Efstathia Ioannou
Received: 6 January 2016 / Revised: 27 January 2016 / Accepted: 1 February 2016 / Published: 4 February 2016
(This article belongs to the Special Issue Triterpenes and Triterpenoids 2016)
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Abstract

Two new oleanane-type saponins, named oleiferasaponins C4 (1) and C5 (2), were isolated from Camellia oleifera Abel. seed cake residue. Their respective structures were identified as 16α-hydroxy-22α-O-angeloyl-23α-aldehyde-28-dihydroxymethylene-olean-12-ene-3β-O-[β-d-galacto-pyranosyl-(1→2)]-[β-d-glucopyranosyl-(1→2)-β-d-galactopyranosy-(1→3)]-β-d-glucopyranosid-uronic acid methyl ester (1) and 16α-hydroxy-22α-O-angeloyl-23α-aldehyde-28-dihydroxy-methylene-olean-12-ene-3β-O-[β-d-galactopyranosyl-(1→2)]-[β-d-galactopyranosyl-(1→3)]-β-d-glucopyranosiduronic acid methyl ester (2) through 1D- and 2D-NMR, HR-ESI-MS, and GC-MS spectroscopic methods. The two compounds exhibited potent cytotoxic activities against five human tumor cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB). View Full-Text
Keywords: Camellia tea oil; saponin; oleiferasaponins; cytotoxic activity Camellia tea oil; saponin; oleiferasaponins; cytotoxic activity
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Zong, J.-F.; Peng, Y.-R.; Bao, G.-H.; Hou, R.-Y.; Wan, X.-C. Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake. Molecules 2016, 21, 188.

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