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Molecules 2016, 21(2), 189; doi:10.3390/molecules21020189

Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids

1
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
2
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo 11371, Egypt
*
Author to whom correspondence should be addressed.
Academic Editors: Jean Jacques Vanden Eynde and Annie Mayence
Received: 18 December 2015 / Revised: 27 January 2016 / Accepted: 29 January 2016 / Published: 4 February 2016
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [793 KB, uploaded 4 February 2016]   |  

Abstract

By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 221 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provides an encouraging framework that could lead to the development of potent new anticancer agents. View Full-Text
Keywords: synthesis; quinazoline; sulfonamides; anticancer activity synthesis; quinazoline; sulfonamides; anticancer activity
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MDPI and ACS Style

Ghorab, M.M.; Alsaid, M.S.; Al-Dosari, M.S.; El-Gazzar, M.G.; Parvez, M.K. Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids. Molecules 2016, 21, 189.

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