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Molecules 2016, 21(11), 1474;

Synthetic Procedures Leading towards Aminobisphosphonates

Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław 50-370, Poland
Author to whom correspondence should be addressed.
Academic Editor: György Keglevich
Received: 30 September 2016 / Revised: 28 October 2016 / Accepted: 2 November 2016 / Published: 4 November 2016
(This article belongs to the Special Issue Recent Advances in Organophosphorus Chemistry)


Growing interest in the biological activity of aminobisphosphonates has stimulated the development of methods for their synthesis. Although several general procedures were previously elaborated to reach this goal, aminobisphosphonate chemistry is still developing quite substantially. Thus, innovative modifications of the existing commonly used reactions, as well as development of new procedures, are presented in this review, concentrating on recent achievements. Additionally, selected examples of aminobisphosphonate derivatization illustrate their usefulness for obtaining new diagnostic and therapeutic agents. View Full-Text
Keywords: bisphosphonates; bisphosphonylation procedures; Vilsmayer-Haack-like reactions; functionalization of aminoalkylbisphosphonates bisphosphonates; bisphosphonylation procedures; Vilsmayer-Haack-like reactions; functionalization of aminoalkylbisphosphonates

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chmielewska, E.; Kafarski, P. Synthetic Procedures Leading towards Aminobisphosphonates. Molecules 2016, 21, 1474.

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