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Molecules 2016, 21(10), 1387; doi:10.3390/molecules21101387

Design, Synthesis and Antifungal Activity of Coumarin Ring-Opening Derivatives

Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing 210095, China
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Academic Editor: Kamal Kumar
Received: 3 September 2016 / Revised: 30 September 2016 / Accepted: 13 October 2016 / Published: 17 October 2016
(This article belongs to the Special Issue Natural Product Inspired Scaffolds Designs)
View Full-Text   |   Download PDF [996 KB, uploaded 17 October 2016]   |  

Abstract

Based on our initial design, we synthesized two series of coumarin ring-opening derivatives by the reactions of hydrolysis and methylation. Results of antifungal screening in vitro showed that the target compounds exhibited potent activity against the six common pathogenic fungi. Compounds 6b, 6e, 6g, 6i, 7b and 7c were identified as the most active ones, and the EC50 values of these active compounds were further tested. Compared to the commonly used fungicide Azoxystrobin (0.0884 µM), compounds 6b (0.0544 µM) and 6e (0.0823 µM) displayed improved activity against Botrytis cinerea. View Full-Text
Keywords: coumarin; strobilurin; synthesis; ring-opening reaction; antifungal activity coumarin; strobilurin; synthesis; ring-opening reaction; antifungal activity
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Zhang, M.-Z.; Zhang, Y.; Wang, J.-Q.; Zhang, W.-H. Design, Synthesis and Antifungal Activity of Coumarin Ring-Opening Derivatives. Molecules 2016, 21, 1387.

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