Synthesis and Antimicrobial Characterization of Half-Calycanthaceous Alkaloid Derivatives
AbstractA total of 29 novel tetrahydropyrroloindol-based calycanthaceous alkaloid derivatives were synthesized from indole-3-acetonitrile in good yields. The synthesized compounds were evaluated against nine strains of bacteria and a wide range of plant pathogen fungi. Bioassay results revealed that majority of the compounds displayed similar or higher in vitro antimicrobial activities than the positive control. The biological activities also indicated that substituents at R4 and R5 significantly affect the activities. Notably, compound c4 was found to be most active among the tested calycanthaceous analogues and might be a novel potential leading compound for further development as an antifungal agent. The results could pave the way for further design and structural modification of calycanthaceous alkaloids as antimicrobial agents. View Full-Text
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Zheng, S.; Zhou, X.; Xu, S.; Zhu, R.; Bai, H.; Zhang, J. Synthesis and Antimicrobial Characterization of Half-Calycanthaceous Alkaloid Derivatives. Molecules 2016, 21, 1207.
Zheng S, Zhou X, Xu S, Zhu R, Bai H, Zhang J. Synthesis and Antimicrobial Characterization of Half-Calycanthaceous Alkaloid Derivatives. Molecules. 2016; 21(9):1207.Chicago/Turabian Style
Zheng, Shaojun; Zhou, Xinping; Xu, Shixun; Zhu, Rui; Bai, Hongjin; Zhang, Jiwen. 2016. "Synthesis and Antimicrobial Characterization of Half-Calycanthaceous Alkaloid Derivatives." Molecules 21, no. 9: 1207.
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