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Molecules 2016, 21(10), 1295;

Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols

Department of Chemistry and Biochemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA
Author to whom correspondence should be addressed.
Academic Editor: György Keglevich
Received: 10 September 2016 / Revised: 18 September 2016 / Accepted: 19 September 2016 / Published: 28 September 2016
(This article belongs to the Special Issue Recent Advances in Organophosphorus Chemistry)
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The Pd-catalyzed direct alkylation of H-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to H-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds R1R2P(O)H. View Full-Text
Keywords: palladium; cross-coupling; alcohols; H-phosphinate esters; allylation; benzylation palladium; cross-coupling; alcohols; H-phosphinate esters; allylation; benzylation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fers-Lidou, A.; Berger, O.; Montchamp, J.-L. Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols. Molecules 2016, 21, 1295.

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